Any treatment can include unwanted side effects, however as consultants will inform you, you are at biggest danger when taking two or extra medicines on the similar time. That is as a result of mixing meds may cause unintended drug interactions, which may vary from delicate to extreme—and even downright lethal. We spoke with Tessa Spencer, PharmD, a specialist in neighborhood pharmacy and practical medication, to seek out out which medicines could also be placing you in hurt’s approach. Learn on to seek out out which 4 mixtures she flagged as being notably harmful, and why they’re decidedly not definitely worth the danger.
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Spencer says that warfarin, which is often prescribed to cut back the chance of blood clots, can grow to be hazardous when blended with the ache reliever ibuprofen. That is as a result of each can “skinny your blood and improve your danger of bleeding, notably within the abdomen,” she explains.
For ache reduction, she as an alternative recommends taking Tylenol, which incorporates the lively ingredient acetaminophen and doesn’t have the identical blood-thinning impact as aspirin or ibuprofen.
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Antidepressants and the dietary complement St. John’s wort are one other mixture Spencer says it’s best to keep away from. For the reason that latter is usually used to enhance signs of melancholy, nervousness, obsessive compulsive dysfunction (OCD), and attention-deficit hyperactivity dysfunction (ADHD), many sufferers run the chance of constructing this error.
“When taken with antidepressants, St. John’s wort could improve your physique’s serotonin ranges. A excessive stage of serotonin may cause numerous signs starting from delicate (shivering and diarrhea) to extreme (muscle rigidity, fever and seizures),” Spencer explains. “In extreme instances, serotonin syndrome may be deadly. It is strongly recommended that you just speak together with your physician earlier than taking this complement along with an antidepressant.”
Thiazide diuretics are sometimes beneficial as a first-line therapy for hypertension. Nonetheless, Spencer warns in opposition to taking this treatment whereas additionally taking calcium dietary supplements or extreme dietary calcium, citing dangers of kidney failure.
“Calcium supplementation mixed with thiazide diuretics, similar to chlorothiazide and hydrochlorothiazide, can result in milk-alkali syndrome, through which the physique has a excessive calcium stage (hypercalcemia),” Spencer explains. “Throughout this course of, the physique experiences an alkaline shift in its acid-base steadiness (metabolic alkalosis) and there is usually a lack of kidney perform.”
Converse together with your physician or pharmacist in case you take thiazide diuretics and are involved that your calcium ranges could exceed suggestions.
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Whereas alcohol is not precisely a drugs, Spencer says it is necessary that individuals understand how harmful it may be to combine it with numerous prescription or over-the-counter medicine—even one thing as generally used as acetaminophen.
“Some people will take Tylenol earlier than or after consuming alcohol to stop or deal with complications related to the alcohol consumption. Nonetheless, there’s a risk of liver harm when consuming alcohol and taking acetaminophen on the similar time,” she warns. “When taken after one night time of consuming, acetaminophen (not more than 4,000mg per day) mustn’t trigger liver harm. Nonetheless, repeated day by day doses of acetaminophen mixed with heavy alcohol use (multiple drink a day for ladies or greater than two drinks a day for me) can result in liver toxicity attributable to acetaminophen.”
Finest Life affords probably the most up-to-date data from high consultants, new analysis, and well being businesses, however our content material just isn’t meant to be an alternative choice to skilled steering. On the subject of the treatment you are taking or every other well being questions you will have, at all times seek the advice of your healthcare supplier instantly.